Reading and Discussion topics

1/7

Introduction to Diffusion

Random Walks in Biology, Howard Berg, Chapter 1 and Chapter 2, Appendix A, Appendix B

RandomWalkScript RandomWalk

(note: you need both files above to run things)

1/14

Optical recording techniques

Review of evanescent wave microscopy (read this before reading papers for discussion 1/25)

Methods in Cellular Imaging. Oxford University Press. 2001. (Chapter 1 by Keith Berland) (read if unfamiliar with fluorescent indicators)

Review of two-photon microscopy

Detailed review of two-photon microscopy (read if interested in technique)

1/18

Diffusion in Biology: Discussion

Steyer and Almers (overview)

Helenius et al.

2/4

Hodgkin and Huxley, 1952, Measurement of current-voltage relations in the membrane of the giant axon of Loligo, J. Physiol 116, 424-448.

Hodgkin and Huxley, 1952, Currents carried by sodium and potassium ions through the membrane of the giant axon of Loligo, J. Physiol 116, 449-472.

Hodgkin and Huxley, 1952, The components of membrane conductance in the giant axon of Loligo, J. Physiol 116, 473-496.

Hodgkin and Huxley, 1952, The dual effect of membrane potential on sodium conductance in the giant axon of Loligo, J. Physiol 116, 497-506.

Hodgkin and Huxley, 1952, A quantitative description of membrane current and its application to conduction and excitation in nerve, J. Physiol 117, 500-544.

2/11

2/22

Hodgkin/Huxley III

2/29

Dendritic computation discussion

Discussion questions

Euler paper

3/3

Nerve, Muscle and Synapse, Bernard Katz, Chapter 9

Del Castillo and Katz. 1954. Quantal components of the end-plate potential. J Physiol 124:560-573.

3/10

Isaacson and Walmsley

Bekkers and Stevens (optional, tour de force application of quantal analysis to central synapse)

Discussion